Ebola is at least 16 million years old, says study

Ebola’s first documented outbreak was in 1976. But the Ebola virus family has been around for 16 to 23 million years, says new research.

The family of viruses to which Ebola and its lethal relative Marburg belong likely existed in the Miocene Epoch at least 16 to 23 million years ago.

At that time, the evolutionary lines leading to Ebola and Marburg had already diverged, according to research that adds to scientists’ developing knowledge about known filoviruses.

Experts once believed filoviruses came into being some 10,000 years ago, coinciding with the rise of agriculture. The new study pushes back the family’s age to the time when great apes arose.

Lead researcher Derek Taylor is a professor of biological sciences at University at Buffalo. He said:

Filoviruses are far more ancient than previously thought. These things have been interacting with mammals for a long time, several million years.

Knowing more about Ebola and Marburg’s comparative evolution could “affect design of vaccines and programs that identify emerging pathogens,” researchers write in the journal PeerJ.

The research does not address the age of the modern-day Ebola virus. Instead, it shows that Ebola and Marburg are each members of ancient evolutionary lines, and that these two viruses last shared a common ancestor sometime prior to 16 to 23 million years ago.

‘Fossil gene’ clues

Taylor and coauthor Jeremy Bruenn, professor of biological sciences, research viral “fossil genes” — chunks of genetic material that animals and other organisms acquire from viruses during infection.

In the new study, the authors report finding remnants of filovirus-like genes in various rodents. One fossil gene, called VP35, appeared in the same spot in the genomes of four different rodent species: two hamsters and two voles. This means the material was likely acquired in or before the Miocene Epoch, prior to when these rodents evolved into distinct species some 16-23 million years ago.

In other words, it appears the known filovirus family is at least as old as the common ancestor of hamsters and voles. Taylor said:

These rodents have billions of base pairs in their genomes, so the odds of a viral gene inserting itself at the same position in different species at different times are very small. It’s likely that the insertion was present in the common ancestor of these rodents.

The genetic material in the VP35 fossil was more closely related to Ebola than to Marburg, indicating that the lines leading to these viruses had already begun diverging from each other in the Miocene.

The new study builds on Taylor’s previous work, which used viral fossil genes to estimate that the entire family of filoviruses was more than 10 million years old. However, those studies used fossil genes only distantly related to Ebola and Marburg, which prevented the researchers from drawing conclusions about the age of these two viral lines.

The new findings fill this viral “fossil gap,” to allow scientists to explore Ebola’s historical relationship with Marburg.

First Ebola outbreak

The first Ebola outbreak in humans occurred in 1976, and scientists still know little about the virus’ history. The same dearth of information applies to Marburg, which was recognized in humans in 1967 and implicated in the death of a Ugandan health worker this month.

Understanding the virus’ ancient past could aid in disease prevention, Taylor says. If a researcher were trying to create a single vaccine effective against both Ebola and Marburg, it could be helpful to know that their evolutionary lineages diverged so long ago.

Knowing more about filoviruses in general could provide insight into which host species might serve as “reservoirs” that harbor undiscovered pathogens related to Ebola and Marburg. Taylor said:

When they first started looking for reservoirs for Ebola, they were crashing through the rainforest, looking at everything—mammals, insects, other organisms. The more we know about the evolution of filovirus-host interactions, the more we can learn about who the players might be in the system.

Bottom line: In a study published in the journal PeerJin October, 2014, scientists say that the family of viruses to which Ebola and its lethal relative Marburg belong likely existed in the Miocene Epoch at least 16 to 23 million years ago.



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